After just three weeks, he landed his first role on General Hospital.
He asked that the character's last name be Katsopolis to highlight his Greek heritage, according to show creator and executive producer Jeff Franklin.
He played one of the show's protagonists, Jesse, who lives with his brother-in-law, whose deceased wife was Jesse's older sister.
That April, he went on to the lead role in the short-lived CBS sitcom Dreams, in which he played an aspiring musician in a band of the same name.
Later, he played a cast role in the sitcom You Again? In the late 1980s, ABC's Full House gradually became a hit, and the show solidified Stamos's career.
At 15, he attended his first Beach Boys concert; a huge fan, he would later tour with the band.
His parents were supportive of his aspiration to be an actor, and although he planned to enroll at Cypress College for the 1981 term, he skipped his first semester to focus on launching a career as an actor—with his father's blessing.Stamos has since maintained close relationships with co-stars Bob Saget, Dave Coulier, Lori Loughlin, Jodie Sweetin, Andrea Barber, and Candace Cameron Bure.Stamos has appeared in numerous made-for-television films, stage productions, television series, and commercials.He took part in only one skit, which featured him in a tree, having rabies, and being put down by another character.In the A&E television movie Wedding Wars (2006), he starred as Shel, a gay wedding planner.In March 2013, Stamos signed on in a recurring role on the USA Network drama Necessary Roughness, during season three.