Panic attacks will not usually return immediately after you stop the medication, but may recur several weeks later. Can be helpful for panic, generalized anxiety, and PTSD. Other side effects are palpitations (changes in heart beat), sweating and drowsiness. The best way to reduce the early anxiety symptoms with the start of imipramine is to begin with a very small dose, typically 10 mg at bed time, and increase the dose 10 mg every day until you reach the dose of 50 mg per day.
These second generation antihistamines are lipophobic and are unable to cross the blood to brain barrier when taken in normal dosages.Their large molecular size and the fact that they have a different ionic charge also impedes this transfer.This means that they prevent histamine from binding with H1 receptors, blocking the chain reaction that would normally lead to the physiological effects produced by histamine.These non-sedating second generation antihistamines are unlikely to cause drowsiness because they do not enter the brain in sufficient quantities.If you stop this medication abruptly, withdrawal symptoms may begin in twenty-four hours, including nausea, tremor, headache, and insomnia. If postural hypotension troubles you, may work more effectively. Therapeutic dose is typically between 50 and 75 mg per day, with some individuals requiring up to 150 mg, based on blood level. Clomipramine (Anafranil) Helps control obsessive-compulsive disorder by reducing the duration and intensity of these symptoms and the corresponding anxiety.
Few symptoms should be evident with a gradual decrease in dose. Imipramine causes some jitteriness in about 20 to 25% of subjects, which usually lasts one to three weeks, but can be often avoided by starting with as little as 10 mg before bed. Some patients, especially males, experience reduced sex drive or responsiveness while taking this drug. Less jitteriness than imipramine; less postural hypotension than other tricyclic antidepressants; lightheadedness, mild sedation (sleepiness), weight gain, insomnia, impaired urination and anticholinergic effects (20% experience dry mouth). Second generation antihistamines do not actually prevent histamine from being released from the mast cells.They are selective peripheral histamine H1 receptor antagonists. For this reason, the medication trial should probably be initiated with a very low dose -- as little as 10 to 25 milligrams (mg) per day of imipramine, for example. Typically taken in one dose at bedtime, but can be divided. Use during pregnancy or breast-feeding only after approval from your physician. Headache, drowsiness, dizziness, nervousness, trouble sleeping, dry mouth, nausea, vomiting, blurred vision, altered taste, sweating, stomach upset, constipation, loss of appetite, anxiety, or yawning may occur. Some people may experience side effects on dosages as low as 10 mg per day: jitteriness, irritation, unusual energy, and difficulty falling or staying asleep. One-third of panic-prone individuals become jittery and actually experience more anxiety symptoms for the first two to three weeks. The sedating side effects can limit productivity and concentration during the day. Consult your physician before using during pregnancy or breast-feeding. Start at 25 to 75 mg per day and increase over one or two weeks to an average dose of 75 to 150 mg and a maximum dose of 300 mg. Nausea and dizziness can be be common side effects. Men with an enlarged prostate should avoid certain antidepressants.