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When an episode seems imminent, Gordon makes sure to communicate openly with Nanjiani.

"When it first happened, [I felt] the guilt of, how could I not see this happening? She can be super sick and still have a great attitude.

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Ten years ago, she was a therapist in Chicago who was eight months into a relationship with the standup comedian.

Gordon initially thought she simply caught a stubborn cold or, at worst, pneumonia.

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"I just have to practice self-care in the ways we all should be doing — get enough sleep, eat healthy and regularly, exercise and keep my stress and drinking down — but I have to be a little more diligent about it because if I slip on any of those, my immune system can act up," Gordon explains of controlling her condition, which she does with Nanjiani's help. At times when I'm not great at self-care, he will force me to be good about it." AOSD can either be episodic or chronic, and its symptoms, which can vary and range in severity, include high fever, skin rashes and joint pain.